{"product_id":"new-product-575298","title":"PLC gamma1(Phospho-Ser1248) Rabbit Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene catalyzes the formation of inositol 1|4|5-trisphosphate and diacylglycerol from phosphatidylinositol 4|5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example| when activated by SRC| the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi| where it activates Ras. Also| this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe PLC-gamma1 phospho-Ser1248 rabbit polyclonal antibody is a highly specific and sensitive tool for the detection and quantification of phosphorylated Ser1248 residues on the PLC-gamma1 protein. This antibody has been meticulously developed and rigorously validated to ensure optimal performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe PLC-gamma1 protein plays a crucial role in intracellular signal transduction pathways, particularly in the regulation of phosphoinositide hydrolysis and calcium mobilization. Phosphorylation of Ser1248 on PLC-gamma1 has been implicated in the modulation of its enzymatic activity and downstream signaling events. Therefore, the ability to specifically detect and quantify this phosphorylation event is of utmost importance in understanding the intricate mechanisms underlying cellular processes.\u003cbr\u003e\u003cbr\u003eThe rabbit polyclonal nature of this antibody ensures high affinity and specificity, enabling reliable and reproducible results. It has been extensively characterized using various experimental approaches, including peptide blocking assays and knockout cell lines, to confirm its specificity for phosphorylated Ser1248 residues on PLC-gamma1. Additionally, this antibody exhibits minimal cross-reactivity with non-phosphorylated forms of PLC-gamma1, further enhancing its specificity.\u003cbr\u003e\u003cbr\u003eThe PLC-gamma1 phospho-Ser1248 rabbit polyclonal antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and error-prone antibody preparation steps. The antibody has been optimized for use in a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.\u003cbr\u003e\u003cbr\u003eIn summary, the PLC-gamma1 phospho-Ser1248 rabbit polyclonal antibody is a reliable and specific tool for the detection and quantification of phosphorylated Ser1248 residues on the PLC-gamma1 protein. Its high sensitivity and versatility make it an invaluable asset for researchers studying signal transduction pathways and cellular processes regulated by PLC-gamma1.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47544360861976,"sku":"BT-AP04182","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_18b626fd-7bb9-4e31-b8f2-2bded8720725.png?v=1705662217","url":"https:\/\/danabiosci.com\/products\/new-product-575298","provider":"Dana Bioscience","version":"1.0","type":"link"}