{"product_id":"new-product-575207","title":"PDHK1(Phospho Tyr243) Rabbit Polyclonal Antibody","description":"\u003cp\u003ePyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation\/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe PDHK1 (Phospho Tyr243) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of PDHK1 protein phosphorylated at Tyr243. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reliability in various applications.\u003cbr\u003e\u003cbr\u003ePDHK1, also known as pyruvate dehydrogenase kinase 1, plays a crucial role in regulating glucose metabolism by phosphorylating and inactivating the pyruvate dehydrogenase complex. The phosphorylation of PDHK1 at Tyr243 has been implicated in the modulation of its enzymatic activity and subsequent downstream effects on cellular metabolism.\u003cbr\u003e\u003cbr\u003eThis antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated PDHK1 and other related proteins, ensuring accurate and reliable results.\u003cbr\u003e\u003cbr\u003eThe PDHK1 (Phospho Tyr243) Rabbit Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without compromising performance. The antibody is stored at -20°C to maintain its stability and activity.\u003cbr\u003e\u003cbr\u003eResearchers and scientists in the fields of metabolism, cell biology, and signal transduction will greatly benefit from the use of this antibody. Its high specificity, sensitivity, and reliability make it an indispensable tool for studying the phosphorylation status and functional implications of PDHK1 at Tyr243.\u003cbr\u003e\u003cbr\u003eIn summary, the PDHK1 (Phospho Tyr243) Rabbit Polyclonal Antibody is a top-quality reagent that enables accurate and precise detection of phosphorylated PDHK1 at Tyr243. Its exceptional performance and versatility make it an essential tool for elucidating the role of PDHK1 in cellular metabolism and related processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47544306467096,"sku":"BT-AP11861","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_c51243c3-0a35-470e-9d02-8733176b661c.png?v=1705661755","url":"https:\/\/danabiosci.com\/products\/new-product-575207","provider":"Dana Bioscience","version":"1.0","type":"link"}