{"product_id":"new-product-574922","title":"NF-κB p105(Phospho Ser903) Rabbit Polyclonal Antibody","description":"\u003cp\u003eGlycine-rich region (GRR) appears to be a critical element in the generation of p50.|The C-terminus of p105 might be involved in cytoplasmic retention| inhibition of DNA-binding| and transcription activation.|NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation| immunity| differentiation| cell growth| tumorigenesis and apoptosis.\u003c\/p\u003e\n\u003cp\u003eNF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA\/p65| RELB| NFKB1\/p105| NFKB1\/p50| REL and NFKB2\/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors| respectively.\u003c\/p\u003e\n\u003cp\u003eNF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway| I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators| subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor| but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing.\u003c\/p\u003e\n\u003cp\u003eThe proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function| although processing of NFKB1\/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3'| located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8| NFKB1\/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1\/p105.|induction:By phorbol ester and TNF-alpha.|PTM:Phosphorylation at 'Ser-903' and 'Ser-907' primes p105 for proteolytic processing in response to TNF-alpha stimulation. Phosphorylation at 'Ser-927' and 'Ser-932' are required for BTRC\/BTRCP-mediated proteolysis.|PTM:Polyubiquitination seems to allow p105 processing.|PTM:S-nitrosylation of Cys-61 affects DNA binding.|PTM:While translation occurs| the particular unfolded structure after the GRR repeat promotes the generation of p50 making it an acceptable substrate for the proteasome.\u003c\/p\u003e\n\u003cp\u003eThis process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like)| being able to form cytosolic complexes with NF-kappa B| trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.|Contains 1 death domain.|Contains 1 RHD (Rel-like) domain.|Contains 7 ANK repeats.|subcellular location:Nuclear| but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).|subunit:Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator| which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1\/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1\/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1\/p50 interacts with NFKBIE. NFKB1\/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID.|\u003c\/p\u003e\n\u003cp\u003eThe NF-ΚB P105(PHOSPHO SER903) Rabbit Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of NF-ΚB P105 protein phosphorylated at serine 903. This antibody has been meticulously developed using advanced immunization techniques and exhibits exceptional sensitivity and specificity.\u003cbr\u003e\u003cbr\u003eThe NF-ΚB P105(PHOSPHO SER903) Rabbit Polyclonal Antibody is designed to recognize and bind to the phosphorylated serine 903 residue of the NF-ΚB P105 protein. This antibody is produced from high-quality rabbit serum, ensuring consistent and reproducible results in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eWith its superior affinity and selectivity, this antibody enables precise and accurate detection of NF-ΚB P105 phosphorylation at serine 903, facilitating in-depth investigations into the functional role of this post-translational modification. Its robust performance and low background noise make it an ideal choice for both qualitative and quantitative analysis of NF-ΚB P105(PHOSPHO SER903) in diverse biological samples.\u003cbr\u003e\u003cbr\u003eThe NF-ΚB P105(PHOSPHO SER903) Rabbit Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. It has been extensively validated and quality-controlled to guarantee consistent performance and reliability.\u003cbr\u003e\u003cbr\u003eChoose the NF-ΚB P105(PHOSPHO SER903) Rabbit Polyclonal Antibody for your research needs and unlock new insights into the intricate mechanisms of NF-ΚB signaling pathway regulation.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47544187257112,"sku":"BT-AP11522","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_1931e334-5279-4f9f-aa39-56e16793a3ff.png?v=1705660267","url":"https:\/\/danabiosci.com\/products\/new-product-574922","provider":"Dana Bioscience","version":"1.0","type":"link"}