{"product_id":"new-product-574749","title":"MMP19 (Cleaved-Tyr98) Rabbit Polyclonal Antibody","description":"\u003cp\u003ealternative products:Additional isoforms seem to exist|Catalytic activity:Cleaves aggrecan at the 360-Ser-|-Phe-361 site.|cofactor:Binds 1 zinc ion per subunit.|cofactor:Calcium.|disease:May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.|The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion| thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.|enzyme regulation:Strongly inhibited by TIMP-2| TIMP-3 and TIMP-4| while TIMP-1 is less efficient.|Endopeptidase that degrades various components of the extracellular matrix| such as aggrecan and cartilage oligomeric matrix protein (comp)| during development| haemostasis and pathological conditions (arthritic disease).\u003c\/p\u003e\n\u003cp\u003eMay also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV| laminin| nidogen| nascin-C isoform| fibronectin| and type I gelatin.|PTM:Activated by autolytic cleavage after Lys-97.|Belongs to the peptidase M10A family.|Contains 4 hemopexin-like domains.|tissue specificity:Expressed in mammary gland| placenta| lung| pancreas| ovary| small intestine| spleen| thymus| prostate| testis colon| heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.|\u003c\/p\u003e\n\u003cp\u003eIntroducing the MMP19 (Cleaved-Tyr98) Rabbit Polyclonal Antibody, a highly specific and reliable tool for the detection and analysis of Matrix Metalloproteinase 19 (MMP19) in various biological samples. This antibody has been meticulously developed and validated to ensure exceptional performance and accuracy in research applications.\u003cbr\u003e\u003cbr\u003eThe MMP19 (Cleaved-Tyr98) Rabbit Polyclonal Antibody exhibits a high affinity towards the cleaved form of MMP19 at Tyr98, making it an ideal choice for investigating the proteolytic activity of MMP19. With its exceptional specificity, this antibody enables precise identification and quantification of MMP19 in complex biological systems.\u003cbr\u003e\u003cbr\u003eThis antibody has been rigorously tested and validated using a variety of techniques, including Western blotting, immunohistochemistry, and immunofluorescence. It consistently demonstrates excellent sensitivity and specificity, providing reliable and reproducible results.\u003cbr\u003e\u003cbr\u003eThe MMP19 (Cleaved-Tyr98) Rabbit Polyclonal Antibody is manufactured using state-of-the-art techniques and high-quality materials to ensure optimal performance and long-term stability. It is supplied as a ready-to-use solution, eliminating the need for time-consuming preparation.\u003cbr\u003e\u003cbr\u003eThis antibody is suitable for a wide range of research applications, including but not limited to, studying the role of MMP19 in tissue remodeling, cancer progression, and inflammatory diseases. Its versatility and reliability make it an indispensable tool for researchers in the field of molecular biology and biomedical sciences.\u003cbr\u003e\u003cbr\u003eIn summary, the MMP19 (Cleaved-Tyr98) Rabbit Polyclonal Antibody offers exceptional specificity, sensitivity, and reliability for the detection and analysis of MMP19. With its high affinity towards the cleaved form of MMP19 at Tyr98, it provides valuable insights into the proteolytic activity of MMP19. Trust in this antibody to deliver accurate and reproducible results, enabling groundbreaking discoveries in the field of biomedical research.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47544148328728,"sku":"BT-AP03632","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_64f68a71-e384-4484-90d5-a8694449b768.png?v=1705659380","url":"https:\/\/danabiosci.com\/products\/new-product-574749","provider":"Dana Bioscience","version":"1.0","type":"link"}