{"product_id":"new-product-574342","title":"Karyopherin alpha2 (Acetyl Lys22) Rabbit Polyclonal Antibody","description":"\u003cp\u003eThe import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog| SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae)| which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J re\u003c\/p\u003e\n\u003cp\u003eThe Karyopherin alpha2 (Acetyl Lys22) Rabbit Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Karyopherin alpha2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the acetylated Lys22 region of Karyopherin alpha2 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for various applications such as Western blotting, immunoprecipitation, and immunohistochemistry.\u003cbr\u003e\u003cbr\u003eThe Karyopherin alpha2 protein is a member of the karyopherin family of nuclear transport receptors, which play a crucial role in the transport of macromolecules such as proteins and RNA between the cytoplasm and the nucleus. The acetylation of Lys22 in Karyopherin alpha2 has been shown to regulate its nuclear import activity, making it an important target for research in the field of nuclear transport.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using protein A chromatography. It is provided in a liquid format, ready for use in various applications. The Karyopherin alpha2 (Acetyl Lys22) Rabbit Polyclonal Antibody is a reliable and high-quality reagent that can help researchers to better understand the role of Karyopherin alpha2 in nuclear transport and other cellular processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47544031936792,"sku":"BT-AP10800","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_651e639d-e941-46ff-90ea-7f2b61f23a7d.png?v=1705657295","url":"https:\/\/danabiosci.com\/products\/new-product-574342","provider":"Dana Bioscience","version":"1.0","type":"link"}