{"product_id":"new-product-574214","title":"IL23A Rabbit Polyclonal Antibody","description":"\u003cp\u003edevelopmental stage:Expressed by newborns dendritic cells.|Associates with IL12B to form the IL-23 interleukin| an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R| activates the Jak-Stat signaling cascade| stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.|induction:Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues| in dendritic cells of multiple sclerosis patients and in tumors.|Belongs to the IL-6 superfamily.|subcellular location:Secreted upon association with IL12B.|subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.|tissue specificity:Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).|\u003c\/p\u003e\n\u003cp\u003eThe IL23A Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IL23A protein in various biological samples. This antibody has been meticulously developed using advanced immunization techniques, resulting in a high affinity and specificity towards IL23A.\u003cbr\u003e\u003cbr\u003eThe IL23A Rabbit Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been rigorously validated to ensure reliable and reproducible results, making it an ideal choice for both research and diagnostic purposes.\u003cbr\u003e\u003cbr\u003eThis antibody offers numerous advantages, including its ability to recognize endogenous levels of IL23A in various species, including human, mouse, and rat. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and specific detection of IL23A.\u003cbr\u003e\u003cbr\u003eThe IL23A Rabbit Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and complex preparation steps. It is provided in a convenient format, allowing for easy storage and handling.\u003cbr\u003e\u003cbr\u003eWith its exceptional sensitivity, specificity, and versatility, the IL23A Rabbit Polyclonal Antibody is an indispensable tool for researchers and clinicians working in the field of immunology and related disciplines. Its reliable performance and ease of use make it an invaluable asset in elucidating the role of IL23A in various physiological and pathological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47544015651096,"sku":"BT-AP10585","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_f1b21950-e747-4380-a67a-cd2e5cc60f68.png?v=1705656681","url":"https:\/\/danabiosci.com\/products\/new-product-574214","provider":"Dana Bioscience","version":"1.0","type":"link"}