{"product_id":"new-product-574122","title":"Histone H4 (Tri Methyl Lys21) Rabbit Polyclonal Antibody","description":"\u003cp\u003eCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin| limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation| DNA repair| DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones| also called histone code| and nucleosome remodeling.\u003c\/p\u003e\n\u003cp\u003e|PTM:Acetylation at Lys-6| Lys-9| Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin.|PTM:Citrullination at Arg-4 by PADI4 impairs methylation.|PTM:Monomethylated| dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.|PTM:Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13. Demethylation is performed by JMJD6.|PTM:Sumoylated| which is associated with transcriptional repression.|PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation.\u003c\/p\u003e\n\u003cp\u003eThis may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.|Belongs to the histone H4 family.|subunit:The nucleosome is a histone octamer containing two molecules each of H2A| H2B| H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543982489880,"sku":"BT-AP10437","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_4d31642e-4f92-47fa-84ff-de9da0a49dd0.png?v=1705656153","url":"https:\/\/danabiosci.com\/products\/new-product-574122","provider":"Dana Bioscience","version":"1.0","type":"link"}