{"product_id":"new-product-573575","title":"ER alpha (Acetyl Lys266) Rabbit Polyclonal Antibody","description":"\u003cp\u003eComposed of three domains: a modulating N-terminal domain| a DNA-binding domain and a C-terminal steroid-binding domain.|Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.|online information:Estrogen receptor entry|polymorphism:Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density| disrutption of bone microarchitecture| and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.|PTM:Glycosylated; contains N-acetylglucosamine| probably O-linked.|PTM:Phosphorylated by cyclin A\/CDK2. Phosphorylation probably enhances transcriptional activity.|Belongs to the nuclear hormone receptor family.|Belongs to the nuclear hormone receptor family. NR3 subfamily.|Contains 1 nuclear receptor DNA-binding domain.|subunit:Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3| NCOA5 and NCOA6 coactivators| leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2| PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2| FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol.|\u003c\/p\u003e\n\u003cp\u003eThe ER Alpha (Acetyl Lys266) Rabbit Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of ER Alpha protein in various biological samples. This antibody has been developed using advanced immunization techniques and exhibits exceptional affinity and sensitivity towards the target protein.\u003cbr\u003e\u003cbr\u003eThe ER Alpha (Acetyl Lys266) Rabbit Polyclonal Antibody is designed to recognize and bind to the acetylated form of Lysine 266 on the ER Alpha protein. This modification plays a crucial role in the regulation of ER Alpha activity and function. By targeting this specific acetylation site, this antibody enables precise and accurate assessment of ER Alpha protein levels and acetylation status.\u003cbr\u003e\u003cbr\u003eThis antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other proteins, ensuring reliable and specific detection of ER Alpha in complex biological samples.\u003cbr\u003e\u003cbr\u003eThe ER Alpha (Acetyl Lys266) Rabbit Polyclonal Antibody is supplied as a purified and concentrated solution, ensuring high quality and consistency. It is compatible with a wide range of experimental conditions and can be used in both research and clinical settings.\u003cbr\u003e\u003cbr\u003eIn summary, the ER Alpha (Acetyl Lys266) Rabbit Polyclonal Antibody is a valuable tool for researchers and clinicians studying ER Alpha protein and its role in various physiological and pathological processes. Its exceptional specificity, sensitivity, and versatility make it an essential component of any study involving ER Alpha protein analysis.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543744364824,"sku":"BT-AP09740","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_62dcf1d7-2071-4dba-91e4-2cee39fa43e3.png?v=1705653239","url":"https:\/\/danabiosci.com\/products\/new-product-573575","provider":"Dana Bioscience","version":"1.0","type":"link"}