{"product_id":"new-product-573040","title":"WRN(Phospho Ser1141) Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism| including transcription| replication| recombination| and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity| and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70\/80 heterodimer in DNA end processing| this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome| an autosomal recessive disorder characterized by premature aging.\u003c\/p\u003e\n\u003cp\u003eThe WRN(Phospho Ser1141) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of the WRN protein phosphorylated at Ser1141. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.\u003cbr\u003e\u003cbr\u003eThe WRN protein plays a crucial role in maintaining genomic stability and DNA repair processes. Phosphorylation of the WRN protein at Ser1141 has been implicated in various cellular processes, including DNA damage response and telomere maintenance. Therefore, the ability to accurately detect and measure the phosphorylation status of WRN at Ser1141 is of great importance in understanding the underlying mechanisms of these processes.\u003cbr\u003e\u003cbr\u003eThis polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other proteins, ensuring reliable and accurate results.\u003cbr\u003e\u003cbr\u003eThe WRN(Phospho Ser1141) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy integration into your experimental workflow. The antibody is also compatible with a wide range of detection methods and can be used in both research and clinical applications.\u003cbr\u003e\u003cbr\u003eWith its exceptional performance and reliability, the WRN(Phospho Ser1141) Polyclonal Antibody is an invaluable tool for researchers and scientists studying DNA repair mechanisms, telomere biology, and related fields. Trust in its quality and specificity to advance your research and gain deeper insights into the intricate workings of cellular processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543531897112,"sku":"BT-AP01821","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_c10a22f4-6ecb-4e78-8877-551e81e1b652.png?v=1705649021","url":"https:\/\/danabiosci.com\/products\/new-product-573040","provider":"Dana Bioscience","version":"1.0","type":"link"}