{"product_id":"new-product-573007","title":"Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody","description":"\u003cp\u003eAlpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus| frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix)| and a short N-terminal triple-helical 7S domain.|Type IV collagen is the major structural component of glomerular basement membranes (GBM)| forming a 'chicken-wire' meshwork together with laminins| proteoglycans and entactin\/nidogen. Potently inhibits angiogenesis and tumor growth.|PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.|PTM:The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.|PTM:Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these| located in the NC1 domain| are conserved in all known type IV collagens.|Belongs to the type IV collagen family.|Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.|subunit:There are six type IV collagen isoforms| alpha 1(IV)-alpha 6(IV)| each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.|\u003c\/p\u003e\n\u003cp\u003eThe Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of Collagen IV alpha2 protein in various biological samples. This antibody has been developed using a rabbit polyclonal approach, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eCollagen IV alpha2 is a crucial component of the basement membrane, playing a vital role in maintaining tissue integrity and function. Cleavage of Collagen IV alpha2 at Ser1485 has been implicated in various pathological conditions, making it an important target for research and diagnostic purposes.\u003cbr\u003e\u003cbr\u003eThe Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody exhibits exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications. It has been rigorously validated to provide reliable and reproducible results, ensuring accurate and precise detection of the target protein.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The antibody is also available in various sizes to accommodate different experimental requirements.\u003cbr\u003e\u003cbr\u003eWith its exceptional specificity, sensitivity, and reliability, the Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody is an indispensable tool for researchers and clinicians involved in studying and diagnosing pathological conditions associated with Collagen IV alpha2 cleavage.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543519019288,"sku":"BT-AP01773","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_66acc1b6-3587-41f3-8ef5-40b59018e29b.png?v=1705648858","url":"https:\/\/danabiosci.com\/products\/new-product-573007","provider":"Dana Bioscience","version":"1.0","type":"link"}