{"product_id":"new-product-572999","title":"Collagen I alpha 1 (Cleaved-Ala1218) Rabbit Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone| cornea| dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV| Ehlers-Danlos syndrome type VIIA| Ehlers-Danlos syndrome Classical type| Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22| where this gene and the gene for platelet-derived growth factor beta are located| are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans| resulting from unregulated expression of the growth factor. Two transcripts| resulting from the use of alternate polyadenylation signals| have been identified for this gene.\u003c\/p\u003e\n\u003cp\u003eThe Collagen I alpha 1 (Cleaved-Ala1218) Rabbit Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of Collagen I alpha 1 protein in various biological samples. This antibody has been developed using high-quality rabbit polyclonal antibodies, ensuring exceptional sensitivity and specificity.\u003cbr\u003e\u003cbr\u003eCollagen I alpha 1 is a crucial component of the extracellular matrix and plays a vital role in maintaining tissue integrity and strength. The Cleaved-Ala1218 variant of Collagen I alpha 1 is generated through proteolytic cleavage and has been implicated in various physiological and pathological processes.\u003cbr\u003e\u003cbr\u003eThis antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent specificity, showing minimal cross-reactivity with other collagen isoforms or related proteins.\u003cbr\u003e\u003cbr\u003eThe Collagen I alpha 1 (Cleaved-Ala1218) Rabbit Polyclonal Antibody is supplied as a ready-to-use solution, ensuring convenience and ease of use. It is provided in a liquid format, allowing for direct application without the need for reconstitution or additional preparation steps.\u003cbr\u003e\u003cbr\u003eWith its exceptional sensitivity, specificity, and ease of use, the Collagen I alpha 1 (Cleaved-Ala1218) Rabbit Polyclonal Antibody is an indispensable tool for researchers and scientists studying collagen biology, extracellular matrix remodeling, and related fields.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543514792216,"sku":"BT-AP01759","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_3f9fedfb-1da9-4bd9-ac6d-82c14ebf2761.png?v=1705648813","url":"https:\/\/danabiosci.com\/products\/new-product-572999","provider":"Dana Bioscience","version":"1.0","type":"link"}