{"product_id":"new-product-572907","title":"CLCN3 Rabbit Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes| and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles| and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)\/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.\u003c\/p\u003e\n\u003cp\u003eThe CLCN3 Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of CLCN3 protein expression in various biological samples. This antibody has been rigorously tested and validated to ensure its reliability and accuracy in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting applications.\u003cbr\u003e\u003cbr\u003eThe CLCN3 protein, also known as chloride channel 3, plays a crucial role in the regulation of chloride ion transport across cell membranes. It is involved in various physiological processes, including cell volume regulation, acidification of intracellular compartments, and membrane potential stabilization. Dysregulation of CLCN3 has been implicated in several diseases, such as cystic fibrosis, epilepsy, and osteoporosis.\u003cbr\u003e\u003cbr\u003eThe CLCN3 Rabbit Polyclonal Antibody has been developed using high-quality rabbit polyclonal antibodies that specifically recognize the CLCN3 protein. It exhibits excellent sensitivity and specificity, enabling the detection of even low levels of CLCN3 expression in various cell types and tissues.\u003cbr\u003e\u003cbr\u003eThis antibody has been extensively validated in different experimental conditions and has shown consistent and reliable results. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and specific detection of CLCN3. Furthermore, it demonstrates excellent signal-to-noise ratio, allowing for clear visualization and quantification of CLCN3 expression.\u003cbr\u003e\u003cbr\u003eThe CLCN3 Rabbit Polyclonal Antibody is supplied as a liquid formulation, ready to use for various applications. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimizing wastage. The antibody is stable and can be stored at -20°C for long-term use.\u003cbr\u003e\u003cbr\u003eIn summary, the CLCN3 Rabbit Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of CLCN3 protein expression. Its excellent sensitivity, specificity, and stability make it an ideal choice for researchers and scientists studying the role of CLCN3 in various biological processes and diseases.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543473471768,"sku":"BT-AP08024","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_ced8e450-5b86-4e9d-9042-2cae4bb54b8e.png?v=1705648357","url":"https:\/\/danabiosci.com\/products\/new-product-572907","provider":"Dana Bioscience","version":"1.0","type":"link"}