{"product_id":"new-product-572887","title":"Smad2\/3(Acetyl-Lys19) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene belongs to the SMAD| a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta| and thus regulates multiple cellular processes| such as cell proliferation| apoptosis| and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal| this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation\u003c\/p\u003e\n\u003cp\u003eThe Smad2\/3(Acetyl-Lys19) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Smad2 and Smad3 proteins in various biological samples. This antibody has been developed using advanced techniques to ensure high affinity and specificity towards the acetylated lysine 19 residue of Smad2 and Smad3 proteins.\u003cbr\u003e\u003cbr\u003eThe Smad2\/3(Acetyl-Lys19) Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. It enables researchers to investigate the role of Smad2 and Smad3 proteins in various cellular processes, such as TGF-β signaling pathway, cell proliferation, differentiation, and apoptosis.\u003cbr\u003e\u003cbr\u003eThis antibody has been rigorously validated for its specificity and sensitivity, ensuring reliable and reproducible results. It has been extensively tested on a variety of cell lines and tissues, demonstrating its ability to specifically recognize the acetylated lysine 19 residue of Smad2 and Smad3 proteins. Furthermore, it exhibits minimal cross-reactivity with other related proteins, ensuring accurate and specific detection.\u003cbr\u003e\u003cbr\u003eThe Smad2\/3(Acetyl-Lys19) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and complex preparation steps. It is provided in a convenient format, allowing for easy and efficient handling in the laboratory. The antibody is also available in different sizes to accommodate various experimental needs.\u003cbr\u003e\u003cbr\u003eIn summary, the Smad2\/3(Acetyl-Lys19) Polyclonal Antibody is a reliable and versatile tool for the detection and analysis of Smad2 and Smad3 proteins. Its high specificity, sensitivity, and ease of use make it an ideal choice for researchers studying TGF-β signaling pathway and related cellular processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543465804056,"sku":"BT-AP07997","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_b3f59e05-b532-4afa-abaf-56c6f19bdece.png?v=1705648258","url":"https:\/\/danabiosci.com\/products\/new-product-572887","provider":"Dana Bioscience","version":"1.0","type":"link"}