{"product_id":"new-product-572862","title":"Separase(Phospho Ser801) Polyclonal Antibody","description":"\u003cp\u003eStable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates| sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1| or separase| which initiates the final separation of sister chromatids (Sun et al.| 2009\u003c\/p\u003e\n\u003cp\u003eThe Separase(Phospho Ser801) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Separase protein phosphorylated at Serine 801. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.\u003cbr\u003e\u003cbr\u003eSeparase is a key regulator of cell division and plays a crucial role in the separation of sister chromatids during mitosis. Phosphorylation of Separase at Serine 801 has been shown to modulate its activity and function, making it an important target for research in cell biology and cancer biology.\u003cbr\u003e\u003cbr\u003eThe Separase(Phospho Ser801) Polyclonal Antibody exhibits exceptional specificity, with minimal cross-reactivity to non-phosphorylated forms of Separase. It has been extensively validated in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy customization and optimization of experimental conditions. The Separase(Phospho Ser801) Polyclonal Antibody is suitable for use in both basic research and clinical applications.\u003cbr\u003e\u003cbr\u003eWith its superior sensitivity and specificity, the Separase(Phospho Ser801) Polyclonal Antibody is an invaluable tool for scientists and researchers studying cell division, mitosis, and related processes. Its reliable performance and consistent results make it an essential component of any laboratory focused on understanding the intricate mechanisms of cellular biology.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543459217688,"sku":"BT-AP07944","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_0f689978-0e26-40ba-b720-452726d9cc20.png?v=1705648122","url":"https:\/\/danabiosci.com\/products\/new-product-572862","provider":"Dana Bioscience","version":"1.0","type":"link"}