{"product_id":"new-product-572748","title":"PKA alpha\/beta\/gamma cat(Phospho Thr198) Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes one of the catalytic subunits of protein kinase A| which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits| in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes| including differentiation| proliferation| and apoptosis. Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Altern\u003c\/p\u003e\n\u003cp\u003eThe PKA alpha\/beta\/gamma cat(Phospho Thr198) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of PKA alpha, beta, and gamma catalytic subunits phosphorylated at Thr198. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eThe PKA alpha\/beta\/gamma cat(Phospho Thr198) Polyclonal Antibody is suitable for various applications, including Western blotting, immunoprecipitation, and immunohistochemistry. It has been extensively validated for its performance in detecting the phosphorylated form of PKA alpha, beta, and gamma catalytic subunits in a wide range of biological samples.\u003cbr\u003e\u003cbr\u003eThis antibody exhibits exceptional sensitivity, allowing for the detection of low abundance phosphorylated PKA alpha, beta, and gamma catalytic subunits. Its high specificity ensures minimal cross-reactivity with non-phosphorylated forms of PKA subunits or other related proteins.\u003cbr\u003e\u003cbr\u003eThe PKA alpha\/beta\/gamma cat(Phospho Thr198) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and complex antibody preparation procedures. It is provided in a convenient format, allowing for easy storage and handling.\u003cbr\u003e\u003cbr\u003eWith its superior performance and reliability, the PKA alpha\/beta\/gamma cat(Phospho Thr198) Polyclonal Antibody is an indispensable tool for researchers studying protein kinase A signaling pathways and investigating the role of PKA alpha, beta, and gamma catalytic subunits in various cellular processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543440638232,"sku":"BT-AP07575","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_04be7293-1210-4a64-a817-191972e7e654.png?v=1705647548","url":"https:\/\/danabiosci.com\/products\/new-product-572748","provider":"Dana Bioscience","version":"1.0","type":"link"}