{"product_id":"new-product-572505","title":"LIMK-2(Phospho Thr505) Polyclonal Antibody","description":"\u003cp\u003eThere are approximately 40 known eukaryotic LIM proteins| so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA| the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK| a downstream effector of Rho| and the encoded protein| in turn| phosphorylates cofilin| inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe LIMK-2(Phospho Thr505) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of LIMK-2 protein phosphorylated at threonine 505 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eThe LIMK-2 protein plays a crucial role in various cellular processes, including cytoskeletal reorganization, cell migration, and cell division. Phosphorylation of LIMK-2 at threonine 505 residue is known to regulate its activity and function. Therefore, the LIMK-2(Phospho Thr505) Polyclonal Antibody serves as an invaluable tool for researchers studying the molecular mechanisms underlying these cellular processes.\u003cbr\u003e\u003cbr\u003eThis antibody has been rigorously validated for its specificity and sensitivity through various experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated LIMK-2 protein, ensuring accurate and reliable results.\u003cbr\u003e\u003cbr\u003eThe LIMK-2(Phospho Thr505) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is available in various sizes to accommodate different experimental needs. Each batch of antibody undergoes stringent quality control measures to ensure consistent performance and reproducibility.\u003cbr\u003e\u003cbr\u003eIn summary, the LIMK-2(Phospho Thr505) Polyclonal Antibody is a highly specific and sensitive tool that enables researchers to investigate the role of LIMK-2 phosphorylation in various cellular processes. Its advanced technology, rigorous validation, and reliable performance make it an essential component of any research project focused on understanding the molecular mechanisms underlying cellular functions.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543359504664,"sku":"BT-AP06917","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_c9277134-a4a3-41c5-b37f-50024cbb6793.png?v=1705646411","url":"https:\/\/danabiosci.com\/products\/new-product-572505","provider":"Dana Bioscience","version":"1.0","type":"link"}