{"product_id":"new-product-572500","title":"Caspase 4 Rabbit Polyclonal Antibody","description":"\u003cp\u003eCatalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.|Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.|PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.|Belongs to the peptidase C14A family.|Contains 1 CARD domain.|subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers| each one formed by a small and a large subunit.|tissue specificity:Widely expressed| with highest levels in spleen and lung. Moderate expression in heart and liver| low expression in skeletal muscle| kidney and testis. Not found in the brain.|\u003c\/p\u003e\n\u003cp\u003eThe Caspase 4 Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of caspase 4 protein in various biological samples. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reliability.\u003cbr\u003e\u003cbr\u003eCaspase 4, also known as caspase-4 or ICH-2, is a member of the caspase family of cysteine proteases. It plays a crucial role in the inflammatory response and is involved in the activation of pro-inflammatory cytokines. The aberrant activation of caspase 4 has been implicated in various diseases, including sepsis, neurodegenerative disorders, and cancer.\u003cbr\u003e\u003cbr\u003eThe Caspase 4 Rabbit Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various experimental conditions. It exhibits minimal cross-reactivity with other caspase family members, ensuring accurate and reliable results. This antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eWith its high affinity and specificity, the Caspase 4 Rabbit Polyclonal Antibody offers researchers a valuable tool for studying the role of caspase 4 in various biological processes and disease states. Its superior performance and reliability make it an essential component of any research project aiming to elucidate the molecular mechanisms underlying caspase 4-mediated signaling pathways.\u003cbr\u003e\u003cbr\u003eOrder the Caspase 4 Rabbit Polyclonal Antibody today and unlock new insights into the function and regulation of caspase 4 in health and disease.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543357800728,"sku":"BT-AP06907","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_bbe4f67e-3ebb-4a90-b661-d3cd90d7af1f.png?v=1705646393","url":"https:\/\/danabiosci.com\/products\/new-product-572500","provider":"Dana Bioscience","version":"1.0","type":"link"}