{"product_id":"new-product-572419","title":"IGF-IR(Phospho Tyr1165\/Y1166) Polyclonal Antibody","description":"\u003cp\u003eThis receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe IGF-IR(Phospho Tyr1165\/Y1166) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of insulin-like growth factor 1 receptor (IGF-IR) phosphorylated at tyrosine residues 1165 and 1166. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the phosphorylated form of IGF-IR.\u003cbr\u003e\u003cbr\u003eThe insulin-like growth factor 1 receptor plays a crucial role in cellular growth, proliferation, and survival. Phosphorylation of tyrosine residues 1165 and 1166 is a key event in the activation of IGF-IR signaling pathway, leading to downstream signaling cascades that regulate various cellular processes. Therefore, the detection and quantification of phosphorylated IGF-IR at these specific sites is of great importance in understanding the molecular mechanisms underlying cellular growth and development.\u003cbr\u003e\u003cbr\u003eThe IGF-IR(Phospho Tyr1165\/Y1166) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated IGF-IR in various biological samples. It has been extensively validated for use in Western blotting, immunoprecipitation, and immunohistochemistry applications. The antibody demonstrates minimal cross-reactivity with non-phosphorylated IGF-IR and other related proteins, ensuring reliable and specific results.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy integration into various experimental protocols. The IGF-IR(Phospho Tyr1165\/Y1166) Polyclonal Antibody is an indispensable tool for researchers and scientists studying the role of IGF-IR phosphorylation in cellular processes, and it promises to deliver accurate and reproducible results in their investigations.\u003cbr\u003e\u003cbr\u003eNote: This product is for research use only and is not intended for diagnostic or therapeutic purposes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543320477976,"sku":"BT-AP06683","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_a5425f37-f0fb-46b8-aacd-13deae906ebf.png?v=1705646012","url":"https:\/\/danabiosci.com\/products\/new-product-572419","provider":"Dana Bioscience","version":"1.0","type":"link"}