{"product_id":"new-product-572380","title":"Histone H3(Phospho Ser10) Polyclonal Antibody","description":"\u003cp\u003eHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome| an octamer composed of pairs of each of the four core histones (H2A| H2B| H3| and H4). The chromatin fiber is further compacted through the interaction of a linker histone| H1| with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead| they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe Histone H3(Phospho Ser10) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Serine 10 residue on Histone H3 protein. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target epitope.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eHistone H3 is a crucial protein involved in chromatin structure and gene regulation. Phosphorylation of Serine 10 on Histone H3 has been implicated in various cellular processes, including mitosis, DNA repair, and transcriptional activation. Therefore, the ability to accurately detect and quantify this phosphorylation event is of utmost importance in understanding the underlying molecular mechanisms.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eThe Histone H3(Phospho Ser10) Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its specificity and sensitivity, ensuring reliable and reproducible results.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eWith its high-quality formulation, this antibody offers excellent signal-to-noise ratio and minimal background interference, enabling precise and accurate quantification of Histone H3 phosphorylation levels. Its polyclonal nature allows for enhanced detection sensitivity, making it an ideal choice for researchers working with limited sample quantities or low abundance targets.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eFurthermore, this antibody is compatible with various sample types, including cell lysates, tissue sections, and whole-cell extracts, providing flexibility and versatility in experimental design. Its robust performance across multiple applications and sample types makes it an indispensable tool for researchers in the fields of epigenetics, cancer biology, and developmental biology.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eIn summary, the Histone H3(Phospho Ser10) Polyclonal Antibody is a reliable and high-performing reagent that enables accurate detection and quantification of phosphorylated Serine 10 on Histone H3. Its exceptional specificity, sensitivity, and versatility make it an essential tool for researchers aiming to unravel the intricate molecular mechanisms underlying cellular processes.\u003c\/span\u003e\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543307305240,"sku":"BT-AP06657","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_4c08be87-9818-4cc9-9403-aecb49213b40.png?v=1705645814","url":"https:\/\/danabiosci.com\/products\/new-product-572380","provider":"Dana Bioscience","version":"1.0","type":"link"}