{"product_id":"new-product-572318","title":"BID (Cleaved-Arg71) Rabbit Polyclonal Antibody","description":"\u003cp\u003eIntact BH3 motif is required by BIK| BID| BAK| BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.|The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1| isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.|PTM:Phosphorylated upon DNA damage| probably by ATM or ATR.|PTM:TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.|subcellular location:A significant proportion of isoform 2 localizes to mitochondria| it may be cleaved constitutively.|subcellular location:Associated with the mitochondrial membrane.|subcellular location:Translocates to mitochondria as an integral membrane protein.|subcellular location:When uncleaved| it is predominantly cytoplasmic.|subunit:Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2.|tissue specificity:Isoforms 2 and 3 are expressed in spleen| bone marrow| cerebral and cerebellar cortex. Isoform 2 is expressed in spleen| pancreas and placenta (at protein level). Isoform 3 is expressed in lung| pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).|\u003c\/p\u003e\n\u003cp\u003eThe BID (Cleaved-Arg71) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of BID protein in various biological samples. This antibody has been meticulously developed using advanced immunization techniques, resulting in a high affinity and specificity towards the cleaved-Arg71 epitope of BID.\u003cbr\u003e\u003cbr\u003eWith its exceptional performance, this antibody offers researchers a reliable and accurate means to investigate the role of BID in various cellular processes, including apoptosis and cell death. Its ability to specifically recognize the cleaved-Arg71 epitope ensures precise detection and quantification of BID protein, enabling researchers to gain valuable insights into the molecular mechanisms underlying these processes.\u003cbr\u003e\u003cbr\u003eThe BID (Cleaved-Arg71) Rabbit Polyclonal Antibody exhibits excellent sensitivity, allowing for the detection of low levels of BID protein in even the most challenging samples. Its robust performance ensures consistent and reproducible results, making it an ideal choice for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eFurthermore, this antibody has been rigorously validated to ensure its reliability and accuracy. It has been extensively tested in various experimental conditions and has consistently demonstrated its specificity towards the cleaved-Arg71 epitope of BID. Its performance has been compared to other commercially available antibodies, and it has consistently outperformed them in terms of sensitivity and specificity.\u003cbr\u003e\u003cbr\u003eIn summary, the BID (Cleaved-Arg71) Rabbit Polyclonal Antibody is a highly reliable and sensitive tool for the detection and quantification of BID protein. Its exceptional performance, coupled with its specificity towards the cleaved-Arg71 epitope, makes it an invaluable asset for researchers studying apoptosis and cell death. Trust in this antibody to deliver accurate and reproducible results, enabling groundbreaking discoveries in the field of molecular biology.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543287415064,"sku":"BT-AP00787","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_f368a93f-a2ea-4e60-95be-11bd676a36a4.png?v=1705645507","url":"https:\/\/danabiosci.com\/products\/new-product-572318","provider":"Dana Bioscience","version":"1.0","type":"link"}