{"product_id":"new-product-572285","title":"BCAR1 Rabbit Polyclonal Antibody","description":"\u003cp\u003eA serine-rich region promotes activation of the serum response element (SRE).|Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK| NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL.|The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1.|Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.|PTM:Focal adhesion kinase 1 phosphorylates the protein at the YDYVHL motif. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix.|Belongs to the CAS family.|Contains 1 SH3 domain.|subcellular location:Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.|subunit:Forms complexes in vivo with focal adhesion kinase 1| adapter protein CRKL and LYN kinase. Can heterodimerize with CASL. Interacts with BCAR3| NPHP1| PTK2B and SH2D3C (By similarity). Interacts with activated CSPG4. Interacts with INPPL1\/SHIP2.|tissue specificity:Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver| thymus| and peripheral blood leukocytes. The protein has been detected in a B-cell line.|\u003c\/p\u003e\n\u003cp\u003eThe BCAR1 Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of BCAR1 protein expression in various biological samples. This antibody has been rigorously tested and validated to ensure its reliability and accuracy in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting applications.\u003cbr\u003e\u003cbr\u003eThe BCAR1 protein, also known as breast cancer anti-estrogen resistance 1, plays a crucial role in cell adhesion, migration, and invasion. It is involved in the development and progression of various cancers, including breast cancer. Therefore, the accurate measurement of BCAR1 protein expression is of great importance in cancer research and diagnosis.\u003cbr\u003e\u003cbr\u003eThe BCAR1 Rabbit Polyclonal Antibody exhibits exceptional specificity towards BCAR1 protein, enabling precise detection and quantification of its expression levels. This antibody has been extensively characterized using a variety of experimental approaches, including knockdown and overexpression studies, to ensure its specificity and sensitivity.\u003cbr\u003e\u003cbr\u003eIn addition to its high specificity, this antibody also demonstrates excellent sensitivity, allowing for the detection of low levels of BCAR1 protein expression. This feature is particularly valuable when working with limited sample amounts or samples with low protein concentrations.\u003cbr\u003e\u003cbr\u003eFurthermore, the BCAR1 Rabbit Polyclonal Antibody has been optimized for use in various experimental techniques, including IHC, IF, and western blotting. It exhibits minimal background staining and provides clear and reliable results, facilitating accurate interpretation and analysis of BCAR1 protein expression patterns.\u003cbr\u003e\u003cbr\u003eOverall, the BCAR1 Rabbit Polyclonal Antibody is a valuable tool for researchers and clinicians involved in cancer research and diagnosis. Its high specificity, sensitivity, and optimized performance in multiple experimental techniques make it an essential component of any study aiming to investigate BCAR1 protein expression and its role in cancer biology.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543277289752,"sku":"BT-AP06283","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_815842b6-28e9-4e04-8a5a-065b359ef317.png?v=1705645353","url":"https:\/\/danabiosci.com\/products\/new-product-572285","provider":"Dana Bioscience","version":"1.0","type":"link"}