{"product_id":"new-product-572274","title":"Flt-3(Phospho Tyr969) Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain| which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis| proliferation| and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.\u003c\/p\u003e\n\u003cp\u003eThe Flt-3(Phospho Tyr969) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Flt-3 protein phosphorylated at tyrosine 969 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eFlt-3, also known as Fms-like tyrosine kinase 3, is a receptor tyrosine kinase that plays a crucial role in hematopoiesis and immune system development. Phosphorylation of Flt-3 at tyrosine 969 residue is known to regulate its downstream signaling pathways, including the activation of PI3K\/AKT and MAPK\/ERK pathways.\u003cbr\u003e\u003cbr\u003eThe Flt-3(Phospho Tyr969) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of phosphorylated Flt-3 protein in complex biological samples.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, ready for immediate use. It is recommended to store the antibody at -20°C for long-term storage to maintain its stability and activity. Prior to use, it is advised to briefly centrifuge the vial to ensure proper mixing.\u003cbr\u003e\u003cbr\u003eThe Flt-3(Phospho Tyr969) Polyclonal Antibody is an indispensable tool for researchers studying the role of Flt-3 phosphorylation in various biological processes, including hematopoiesis, immune response, and cancer development. Its high quality and reliability make it an ideal choice for both basic research and clinical applications.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543272800536,"sku":"BT-AP06272","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_e1d36723-31d1-42f6-858f-956a8ffd7bcd.png?v=1705645299","url":"https:\/\/danabiosci.com\/products\/new-product-572274","provider":"Dana Bioscience","version":"1.0","type":"link"}