{"product_id":"new-product-572186","title":"ASK1(Phospho-Thr845) Rabbit Polyclonal Antibody","description":"\u003cp\u003eMitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK)| MAPK kinase (MKK or MEK)| and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase\/MEKK phosphorylates and activates its downstream protein kinase| MAPK kinase\/MEK| which in turn activates MAPK. The kinases of these signaling cascades are highly conserved| and homologs exist in yeast| Drosophila| and mammalian cells. MAPKKK5 contains 1|374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1| MAPKK4) in vitro| and activates c-Jun N-terminal kinase (JNK)\/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK\/ERK.\u003c\/p\u003e\n\u003cp\u003eThe ASK1(Phospho-Thr845) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of ASK1 protein phosphorylated at threonine 845. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reliability in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe ASK1(Phospho-Thr845) Rabbit Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of ASK1 at threonine 845, enabling accurate and precise analysis of ASK1 activation and signaling pathways. Its high sensitivity allows for the detection of low levels of phosphorylated ASK1, making it an ideal choice for studying ASK1-related cellular processes and diseases.\u003cbr\u003e\u003cbr\u003eThis antibody has been extensively validated and optimized to provide consistent and reproducible results. It exhibits minimal cross-reactivity with non-phosphorylated ASK1 and other related proteins, ensuring reliable and specific detection of the phosphorylated form. Its robust performance and low background noise make it an invaluable tool for researchers in the field of signal transduction and cellular signaling.\u003cbr\u003e\u003cbr\u003eThe ASK1(Phospho-Thr845) Rabbit Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy handling and storage. Each batch of antibody undergoes rigorous quality control procedures to ensure its performance and reliability, guaranteeing consistent results from experiment to experiment.\u003cbr\u003e\u003cbr\u003eIn summary, the ASK1(Phospho-Thr845) Rabbit Polyclonal Antibody is a highly specific and sensitive tool that enables accurate detection and quantification of phosphorylated ASK1 at threonine 845. Its exceptional performance, reliability, and versatility make it an indispensable asset for researchers studying ASK1-related cellular processes and diseases.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543244194072,"sku":"BT-AP06120","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_7dc120b0-7636-431e-9e08-596d3068c2b8.png?v=1705644909","url":"https:\/\/danabiosci.com\/products\/new-product-572186","provider":"Dana Bioscience","version":"1.0","type":"link"}