{"product_id":"new-product-572155","title":"AS160(Phospho-Ser318) Rabbit Polyclonal Antibody","description":"\u003cp\u003eThis gene is a member of the Tre-2\/BUB2\/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein| and contains two phopshotyrosine-binding domains (PTB1 and PTB2)| a calmodulin-binding domain (CBD)| a Rab-GTPase domain| and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4)| important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane| suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin| this protein is phosphorylated| dissociates from GLUT4 vesicles| resulting in increased GLUT4 at the cell surface| and enhanced glucose transport. Ph\u003c\/p\u003e\n\u003cp\u003eThe AS160(Phospho-Ser318) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of AS160 protein phosphorylated at Serine 318. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring reliable and reproducible results.\u003cbr\u003e\u003cbr\u003eAS160, also known as TBC1D4, is a key regulator of glucose uptake in skeletal muscle and adipocytes. Phosphorylation of AS160 at Serine 318 plays a crucial role in insulin-stimulated glucose transport by promoting the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Therefore, the AS160(Phospho-Ser318) Rabbit Polyclonal Antibody is an essential tool for studying the molecular mechanisms underlying glucose metabolism and insulin signaling.\u003cbr\u003e\u003cbr\u003eThis antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated AS160 and other related proteins, ensuring accurate and reliable detection of AS160 phosphorylated at Serine 318.\u003cbr\u003e\u003cbr\u003eThe AS160(Phospho-Ser318) Rabbit Polyclonal Antibody is supplied as a liquid formulation in a convenient size of 100 μg. It is recommended for use in a wide range of applications, including basic research, drug discovery, and clinical diagnostics. With its high specificity, sensitivity, and reproducibility, this antibody is an indispensable tool for researchers and scientists studying glucose metabolism, insulin signaling, and related pathways.\u003cbr\u003e\u003cbr\u003eOrder your AS160(Phospho-Ser318) Rabbit Polyclonal Antibody today and unlock new insights into the intricate mechanisms governing glucose uptake and insulin signaling.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543231873304,"sku":"BT-AP06039","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_fac5b56a-c712-4b6d-8234-96cd8ac27915.png?v=1705644769","url":"https:\/\/danabiosci.com\/products\/new-product-572155","provider":"Dana Bioscience","version":"1.0","type":"link"}