{"product_id":"new-product-572023","title":"ALK(Phospho-Tyr1278) Rabbit Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a receptor tyrosine kinase| which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain| an hydrophobic stretch corresponding to a single pass transmembrane region| and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged| mutated| or amplified in a series of tumours including anaplastic large cell lymphomas| neuroblastoma| and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene| which result in creation of multiple fusion genes in tumourigenesis| including ALK (chromosome 2)\/EML4 (chromosome 2)| ALK\/RANBP2 (chromosome 2)| ALK\/ATIC (chromosome 2)| ALK\/TFG (chromosome 3)| ALK\/NPM1 (chromosome 5)| ALK\/SQSTM1 (chromosome\u003c\/p\u003e\n\u003cp\u003eThe ALK(Phospho-Tyr1278) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of ALK protein phosphorylated at tyrosine 1278. This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry.\u003cbr\u003e\u003cbr\u003eThe ALK protein, also known as anaplastic lymphoma kinase, plays a crucial role in cell growth, differentiation, and survival. Dysregulation of ALK signaling has been implicated in various cancers, making it an important target for therapeutic intervention. The phosphorylation of tyrosine 1278 in ALK is a key event in the activation of its downstream signaling pathways.\u003cbr\u003e\u003cbr\u003eOur ALK(Phospho-Tyr1278) Rabbit Polyclonal Antibody has been developed using high-quality rabbit polyclonal antibodies that have been carefully selected and validated for their specificity and sensitivity. This ensures reliable and reproducible results in your experiments.\u003cbr\u003e\u003cbr\u003eThe antibody has been optimized for use in Western blotting, allowing for the detection of ALK protein phosphorylated at tyrosine 1278 in cell lysates or tissue extracts. It exhibits a high signal-to-noise ratio and minimal background, enabling accurate quantification of ALK phosphorylation levels.\u003cbr\u003e\u003cbr\u003eIn addition to Western blotting, this antibody can also be used for immunoprecipitation to isolate and study ALK protein complexes, as well as for immunohistochemistry to visualize the localization and distribution of phosphorylated ALK in tissue sections.\u003cbr\u003e\u003cbr\u003eThe ALK(Phospho-Tyr1278) Rabbit Polyclonal Antibody is supplied as a liquid formulation in a convenient size of 100 μg. It is provided in a ready-to-use format, eliminating the need for time-consuming antibody preparation. The antibody has been quality tested to ensure consistent performance and is guaranteed to meet the highest standards of quality and reliability.\u003cbr\u003e\u003cbr\u003eIn summary, the ALK(Phospho-Tyr1278) Rabbit Polyclonal Antibody is a valuable tool for researchers studying ALK signaling and its role in cancer biology. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory working in the field of molecular biology and oncology.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543170728216,"sku":"BT-AP01623","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_6bc5c1ac-1a21-46c3-8111-64a49d638f85.png?v=1705644074","url":"https:\/\/danabiosci.com\/products\/new-product-572023","provider":"Dana Bioscience","version":"1.0","type":"link"}