{"product_id":"new-product-571878","title":"IGF-I Receptor beta(Phospho-Tyr1135) Rabbit Polyclonal Antibody","description":"\u003cp\u003eThis receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe IGF-I Receptor beta(Phospho-Tyr1135) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of the phosphorylated form of the IGF-I receptor beta subunit at tyrosine 1135 residue. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reliability in various applications.\u003cbr\u003e\u003cbr\u003eThe IGF-I receptor beta plays a crucial role in mediating the biological effects of insulin-like growth factor-I (IGF-I), a key regulator of cell growth, differentiation, and survival. Phosphorylation of the receptor at tyrosine 1135 residue is known to be involved in the activation of downstream signaling pathways, including the PI3K\/AKT and MAPK\/ERK pathways, which are essential for cellular proliferation and survival.\u003cbr\u003e\u003cbr\u003eThis antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results. Additionally, this antibody has been optimized for use in multiple species, including human, mouse, and rat, making it a versatile tool for researchers working in different fields.\u003cbr\u003e\u003cbr\u003eThe IGF-I Receptor beta(Phospho-Tyr1135) Rabbit Polyclonal Antibody is supplied as a liquid formulation, ready to use for immediate application. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. Each batch of this antibody undergoes rigorous quality control procedures to ensure consistent performance and batch-to-batch reproducibility.\u003cbr\u003e\u003cbr\u003eIn summary, the IGF-I Receptor beta(Phospho-Tyr1135) Rabbit Polyclonal Antibody is a reliable and specific tool for the detection and quantification of the phosphorylated form of the IGF-I receptor beta subunit. Its high sensitivity, excellent specificity, and versatility make it an ideal choice for researchers studying the role of IGF-I receptor signaling in various biological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543116300568,"sku":"BT-AP00100","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_eb51e2ff-7be4-44d0-97a2-73f078be3b19.png?v=1705643379","url":"https:\/\/danabiosci.com\/products\/new-product-571878","provider":"Dana Bioscience","version":"1.0","type":"link"}