{"product_id":"new-product-571761","title":"Phospho-BLNK (Y84) Polyclonal Antibody","description":"\u003cp\u003eBLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. B-cell linker bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe Phospho-BLNK (Y84) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated B cell linker protein (BLNK) at tyrosine 84 residue. BLNK plays a crucial role in B cell receptor (BCR) signaling and is involved in the activation of various downstream signaling pathways.\u003cbr\u003e\u003cbr\u003eThis polyclonal antibody has been meticulously developed using advanced immunization techniques and exhibits exceptional affinity and selectivity towards phosphorylated BLNK at tyrosine 84. It has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe Phospho-BLNK (Y84) Polyclonal Antibody offers researchers a reliable and robust tool to investigate the phosphorylation status of BLNK at tyrosine 84 in diverse biological samples. Its high specificity ensures minimal cross-reactivity with non-phosphorylated BLNK or other proteins, thereby providing accurate and precise results.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, ready for immediate use in various applications, including but not limited to, protein-protein interaction studies, signal transduction analysis, and cellular localization studies. It is compatible with multiple detection methods, such as chemiluminescence, fluorescence, and colorimetric assays.\u003cbr\u003e\u003cbr\u003eWith its exceptional performance characteristics and reliable results, the Phospho-BLNK (Y84) Polyclonal Antibody is an indispensable tool for researchers in the fields of immunology, cell biology, and molecular biology. It enables in-depth investigations into the phosphorylation-mediated regulation of BLNK and its implications in BCR signaling pathways, ultimately contributing to a better understanding of immune responses and potential therapeutic targets.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543053222168,"sku":"BT-PHS00802","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_b48c8a48-5278-47f3-b9bf-5e59bf630a49.png?v=1705642798","url":"https:\/\/danabiosci.com\/products\/new-product-571761","provider":"Dana Bioscience","version":"1.0","type":"link"}