{"product_id":"new-product-571757","title":"Phospho-Akt1\/3 (Y437\/434) Polyclonal Antibody","description":"\u003cp\u003eThe serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine\/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for AKT1.\u003c\/p\u003e\n\u003cp\u003eThe Phospho-Akt1\/3 (Y437\/434) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Akt1 and Akt3 proteins. This antibody is produced using advanced techniques, ensuring high affinity and specificity towards the phosphorylated form of Akt1 and Akt3 at the Y437 and Y434 residues, respectively.\u003cbr\u003e\u003cbr\u003eThe Phospho-Akt1\/3 (Y437\/434) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It enables researchers to investigate the activation status of Akt1 and Akt3 in diverse biological samples, providing valuable insights into cellular signaling pathways and their involvement in various physiological and pathological processes.\u003cbr\u003e\u003cbr\u003eWith its superior sensitivity and specificity, this antibody offers reliable and reproducible results, allowing for accurate quantification of phosphorylated Akt1 and Akt3 levels. Its polyclonal nature ensures robust detection, minimizing the risk of false negatives or positives. Moreover, the antibody has been extensively validated in multiple experimental settings, guaranteeing consistent and trustworthy outcomes.\u003cbr\u003e\u003cbr\u003eThe Phospho-Akt1\/3 (Y437\/434) Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. It is provided in a liquid formulation, allowing for straightforward handling and minimizing the risk of sample loss or contamination.\u003cbr\u003e\u003cbr\u003eIn summary, the Phospho-Akt1\/3 (Y437\/434) Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of phosphorylated Akt1 and Akt3 proteins. Its high specificity, sensitivity, and versatility make it an indispensable asset for researchers studying cellular signaling pathways and their implications in various biological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543048831256,"sku":"BT-PHS00778","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_cda95417-0db3-4ce6-87d3-61c3731f473c.png?v=1705642763","url":"https:\/\/danabiosci.com\/products\/new-product-571757","provider":"Dana Bioscience","version":"1.0","type":"link"}