{"product_id":"new-product-571756","title":"Phospho-Catenin-Beta (Y489) Polyclonal Antibody","description":"\u003cp\u003eCatenin beta-1 encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe Phospho-Catenin-Beta (Y489) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Catenin-Beta protein. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.\u003cbr\u003e\u003cbr\u003eCatenin-Beta is a key component of the Wnt signaling pathway, which plays a crucial role in various cellular processes, including cell proliferation, differentiation, and development. Phosphorylation of Catenin-Beta at tyrosine 489 residue has been implicated in the regulation of its stability and activity, making it an important target for research in the field of signal transduction.\u003cbr\u003e\u003cbr\u003eThe Phospho-Catenin-Beta (Y489) Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of Catenin-Beta, enabling accurate detection and quantification of this modified protein. It has been extensively validated in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence, ensuring its suitability for a wide range of applications.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for efficient and cost-effective experimentation. The Phospho-Catenin-Beta (Y489) Polyclonal Antibody is compatible with multiple species, including human, mouse, and rat, facilitating its utilization in diverse research models.\u003cbr\u003e\u003cbr\u003eWith its exceptional sensitivity, specificity, and versatility, the Phospho-Catenin-Beta (Y489) Polyclonal Antibody is an indispensable tool for scientists and researchers investigating the intricate mechanisms of Wnt signaling and its implications in various physiological and pathological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543048798488,"sku":"BT-PHS00768","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_6323ab9a-2f2e-4255-ac43-59fa5b250637.png?v=1705642759","url":"https:\/\/danabiosci.com\/products\/new-product-571756","provider":"Dana Bioscience","version":"1.0","type":"link"}