{"product_id":"new-product-571730","title":"Phospho-Akt (S124) Polyclonal Antibody","description":"\u003cp\u003eThe serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine\/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eIntroducing the Phospho-Akt (S124) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate accurate and reliable detection of phosphorylated Akt at serine 124 residue. This high-quality antibody is specifically engineered to exhibit exceptional sensitivity and specificity, enabling researchers to delve into the intricate mechanisms underlying Akt signaling pathways with utmost precision.\u003cbr\u003e\u003cbr\u003eCrafted with utmost care and precision, this polyclonal antibody is derived from a diverse pool of host animals, ensuring a broad spectrum of epitope recognition. Through a rigorous purification process, the antibody attains an unparalleled level of purity, guaranteeing minimal background noise and maximizing signal-to-noise ratio for optimal experimental outcomes.\u003cbr\u003e\u003cbr\u003eThe Phospho-Akt (S124) Polyclonal Antibody boasts an exceptional affinity for phosphorylated Akt at serine 124, enabling researchers to confidently explore the intricate phosphorylation events that govern Akt activation and downstream signaling cascades. Its remarkable specificity ensures minimal cross-reactivity with non-phosphorylated Akt, thereby facilitating accurate and reliable detection of the phosphorylated form.\u003cbr\u003e\u003cbr\u003eThis antibody's versatility is further enhanced by its compatibility with various applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its robust performance across multiple experimental platforms empowers researchers to seamlessly integrate it into their preferred methodologies, thereby facilitating comprehensive investigations into Akt signaling dynamics.\u003cbr\u003e\u003cbr\u003eWith the Phospho-Akt (S124) Polyclonal Antibody, researchers can unlock a deeper understanding of Akt-mediated cellular processes, such as cell survival, proliferation, and metabolism. By elucidating the intricate phosphorylation events governing Akt activation, this antibody paves the way for groundbreaking discoveries and novel therapeutic interventions targeting Akt signaling pathways.\u003cbr\u003e\u003cbr\u003eIn summary, the Phospho-Akt (S124) Polyclonal Antibody stands as an indispensable tool for researchers seeking to unravel the complexities of Akt signaling. Its exceptional sensitivity, specificity, and versatility make it an invaluable asset in elucidating the role of Akt phosphorylation in various physiological and pathological contexts. Trust in this meticulously crafted antibody to elevate your research endeavors to unprecedented heights.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543036936472,"sku":"BT-PHS00621","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_5f5b5928-7534-454c-bd48-4fc39d4f1bfe.png?v=1705642630","url":"https:\/\/danabiosci.com\/products\/new-product-571730","provider":"Dana Bioscience","version":"1.0","type":"link"}