{"product_id":"new-product-571715","title":"Phospho-c-Abl (Y245) Polyclonal Antibody","description":"\u003cp\u003eABL1 is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM: 151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.\u003c\/p\u003e\n\u003cp\u003eThe Phospho-c-Abl (Y245) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated c-Abl protein at tyrosine 245 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eThe c-Abl protein plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. Phosphorylation of c-Abl at tyrosine 245 residue has been implicated in the regulation of its kinase activity and downstream signaling pathways. Therefore, the Phospho-c-Abl (Y245) Polyclonal Antibody serves as an invaluable tool for researchers studying the functional significance of c-Abl phosphorylation in various biological contexts.\u003cbr\u003e\u003cbr\u003eThis antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated c-Abl protein in complex biological samples.\u003cbr\u003e\u003cbr\u003eThe Phospho-c-Abl (Y245) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation. It is compatible with a wide range of experimental conditions and can be used in both routine laboratory settings and high-throughput screening applications.\u003cbr\u003e\u003cbr\u003eIn summary, the Phospho-c-Abl (Y245) Polyclonal Antibody is a powerful research tool that enables the investigation of c-Abl phosphorylation events with high precision and accuracy. Its exceptional sensitivity, specificity, and versatility make it an indispensable asset for scientists and researchers in the field of cellular signaling and cancer biology.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543028777240,"sku":"BT-PHS00534","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_db2e3d00-421f-49cf-a171-2c2a00a0d320.png?v=1705642546","url":"https:\/\/danabiosci.com\/products\/new-product-571715","provider":"Dana Bioscience","version":"1.0","type":"link"}