{"product_id":"new-product-571706","title":"Phospho-BRCA1 (S1457) Polyclonal Antibody","description":"\u003cp\u003eBRCA1 (BRCA1, DNA repair associated) encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in BRCA1 are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for BRCA1, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.\u003c\/p\u003e\n\u003cp\u003eIntroducing the Phospho-BRCA1 (S1457) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling precise detection and analysis of the phosphorylated form of BRCA1 at serine 1457 residue.\u003cbr\u003e\u003cbr\u003eCrafted with utmost precision and utilizing state-of-the-art technology, this antibody offers researchers an invaluable resource to unravel the intricate mechanisms underlying BRCA1 phosphorylation. Its polyclonal nature ensures a diverse range of epitope recognition, enhancing the versatility and reliability of experimental outcomes.\u003cbr\u003e\u003cbr\u003eThe Phospho-BRCA1 (S1457) Polyclonal Antibody boasts an exceptional affinity for the phosphorylated form of BRCA1 at serine 1457, enabling researchers to explore the dynamic phosphorylation events associated with this critical residue. This antibody's high specificity guarantees minimal cross-reactivity, ensuring accurate and reliable results.\u003cbr\u003e\u003cbr\u003eWith its robust performance, this antibody is ideally suited for various applications, including Western blotting, immunoprecipitation, and immunofluorescence. Its compatibility with multiple experimental techniques empowers researchers to investigate the role of BRCA1 phosphorylation in diverse cellular contexts, shedding light on its involvement in crucial biological processes.\u003cbr\u003e\u003cbr\u003eFurthermore, the Phospho-BRCA1 (S1457) Polyclonal Antibody exhibits exceptional sensitivity, enabling the detection of low-abundance phosphorylated BRCA1 species. This heightened sensitivity broadens the scope of research possibilities, facilitating the exploration of subtle phosphorylation dynamics and their functional implications.\u003cbr\u003e\u003cbr\u003eIn summary, the Phospho-BRCA1 (S1457) Polyclonal Antibody represents a breakthrough in molecular biology research, offering scientists an indispensable tool to investigate the phosphorylation events associated with BRCA1 at serine 1457. Its exceptional specificity, sensitivity, and compatibility with various experimental techniques make it an invaluable asset for unraveling the intricate mechanisms underlying BRCA1-mediated cellular processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543021535512,"sku":"BT-PHS00462","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_e7a29daa-3004-43c5-96d0-a800142a49a4.png?v=1705642499","url":"https:\/\/danabiosci.com\/products\/new-product-571706","provider":"Dana Bioscience","version":"1.0","type":"link"}