{"product_id":"new-product-571663","title":"Phospho-BRCA1 (S1524) Polyclonal Antibody","description":"\u003cp\u003eBRCA1 (BRCA1, DNA repair associated) encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in BRCA1 are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for BRCA1, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.\u003c\/p\u003e\n\u003cp\u003eIntroducing the Phospho-BRCA1 (S1524) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling precise detection and analysis of the phosphorylated form of BRCA1 at serine 1524.\u003cbr\u003e\u003cbr\u003eCrafted with utmost precision and utilizing state-of-the-art technology, this antibody offers researchers an invaluable resource for investigating the intricate mechanisms underlying BRCA1 phosphorylation. Its polyclonal nature ensures a diverse range of epitope recognition, enhancing the versatility and reliability of experimental outcomes.\u003cbr\u003e\u003cbr\u003eThe Phospho-BRCA1 (S1524) Polyclonal Antibody boasts an exceptional affinity for the phosphorylated form of BRCA1 at serine 1524, enabling researchers to discern even the subtlest changes in phosphorylation levels. This antibody's high specificity guarantees minimal cross-reactivity, ensuring accurate and reliable results.\u003cbr\u003e\u003cbr\u003eWith its robust performance and exceptional sensitivity, this antibody is an indispensable tool for elucidating the role of BRCA1 phosphorylation in various cellular processes, including DNA repair, cell cycle regulation, and tumor suppression. Its application extends to a wide array of experimental techniques, including Western blotting, immunoprecipitation, and immunofluorescence, empowering researchers to explore the intricate intricacies of BRCA1 signaling pathways.\u003cbr\u003e\u003cbr\u003eThe Phospho-BRCA1 (S1524) Polyclonal Antibody is meticulously manufactured under stringent quality control measures, ensuring consistent and reproducible results across experiments. Each batch undergoes rigorous validation to guarantee optimal performance, providing researchers with the utmost confidence in their findings.\u003cbr\u003e\u003cbr\u003eIn summary, the Phospho-BRCA1 (S1524) Polyclonal Antibody represents a pinnacle of scientific innovation, offering researchers an indispensable tool for investigating the complex world of BRCA1 phosphorylation. Its exceptional specificity, sensitivity, and versatility make it an invaluable asset in unraveling the intricate mechanisms governing cellular processes. Elevate your research to new heights with this remarkable antibody, and unlock the secrets of BRCA1 phosphorylation with unparalleled precision and accuracy.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543004758296,"sku":"BT-PHS00039","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_4e079d51-b711-4c3a-83c1-1f57deea0db0.png?v=1705642280","url":"https:\/\/danabiosci.com\/products\/new-product-571663","provider":"Dana Bioscience","version":"1.0","type":"link"}