{"product_id":"new-product-571658","title":"Phospho-Bcl-x (S62) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by BCL2L1 (BCL2 like 1) belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.\u003c\/p\u003e\n\u003cp\u003eThe Phospho-Bcl-x (S62) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Bcl-x at serine 62. Bcl-x is a member of the Bcl-2 family of proteins, which play a crucial role in regulating apoptosis, or programmed cell death. Phosphorylation of Bcl-x at serine 62 has been shown to modulate its anti-apoptotic activity, making it an important target for research in the field of cell biology and cancer.\u003cbr\u003e\u003cbr\u003eThis polyclonal antibody has been carefully developed and validated to ensure its specificity and reliability. It has been extensively tested in various experimental conditions, including Western blotting, immunoprecipitation, and immunofluorescence, to provide accurate and reproducible results. The antibody exhibits minimal cross-reactivity with other proteins, ensuring the specificity of the detected signal.\u003cbr\u003e\u003cbr\u003eThe Phospho-Bcl-x (S62) Polyclonal Antibody is supplied as a liquid formulation, ready to use for various applications. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The antibody is produced using high-quality materials and rigorous manufacturing processes to ensure batch-to-batch consistency and reliability.\u003cbr\u003e\u003cbr\u003eResearchers and scientists can confidently utilize this antibody to investigate the role of phosphorylated Bcl-x in cellular processes, such as apoptosis, cell survival, and cancer progression. Its high sensitivity and specificity make it an invaluable tool for studying the intricate mechanisms underlying these biological phenomena.\u003cbr\u003e\u003cbr\u003eIn summary, the Phospho-Bcl-x (S62) Polyclonal Antibody is a reliable and specific reagent that enables accurate detection and quantification of phosphorylated Bcl-x at serine 62. Its versatility and robust performance make it an essential tool for researchers in the fields of cell biology, cancer research, and beyond.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47543000236312,"sku":"BT-PHS00034","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_4b1215ea-a113-48c1-8d25-5a6191f1784a.png?v=1705642260","url":"https:\/\/danabiosci.com\/products\/new-product-571658","provider":"Dana Bioscience","version":"1.0","type":"link"}