{"product_id":"new-product-571630","title":"Phospho-Akt1 (S246) Polyclonal Antibody","description":"\u003cp\u003eThe serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine\/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for AKT1.\u003c\/p\u003e\n\u003cp\u003eIntroducing the Phospho-Akt1 (S246) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate accurate and reliable detection of phosphorylated Akt1 at serine 246. This antibody, crafted with utmost precision and expertise, offers an unparalleled opportunity to delve into the intricate world of Akt1 signaling pathways.\u003cbr\u003e\u003cbr\u003eThe Phospho-Akt1 (S246) Polyclonal Antibody showcases exceptional specificity and sensitivity, enabling researchers to discern even the minutest changes in Akt1 phosphorylation status. Its polyclonal nature ensures a broad recognition spectrum, allowing for comprehensive analysis across various experimental models and biological systems.\u003cbr\u003e\u003cbr\u003eWith its robust performance, this antibody serves as an invaluable asset in elucidating the role of Akt1 phosphorylation at serine 246 in diverse cellular processes, including cell survival, proliferation, and metabolism. By facilitating the investigation of Akt1 signaling dynamics, this antibody empowers researchers to unravel the complex mechanisms underlying numerous physiological and pathological conditions.\u003cbr\u003e\u003cbr\u003eFurthermore, the Phospho-Akt1 (S246) Polyclonal Antibody exhibits exceptional versatility, accommodating a wide range of applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Its compatibility with multiple experimental techniques ensures seamless integration into various research workflows, thereby enhancing experimental flexibility and efficiency.\u003cbr\u003e\u003cbr\u003eManufactured under stringent quality control measures, this antibody guarantees reproducibility and consistency, enabling researchers to obtain reliable and robust results with every experiment. Its exceptional performance characteristics, coupled with its user-friendly nature, make it an indispensable tool for both seasoned scientists and aspiring researchers alike.\u003cbr\u003e\u003cbr\u003eIn summary, the Phospho-Akt1 (S246) Polyclonal Antibody represents a pinnacle of scientific innovation, offering an unparalleled opportunity to unravel the intricate world of Akt1 signaling. With its exceptional specificity, sensitivity, versatility, and reliability, this antibody serves as an indispensable asset in elucidating the role of Akt1 phosphorylation at serine 246 in various biological processes. Embrace the power of this cutting-edge scientific tool and unlock new frontiers in cellular signaling research.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542985097496,"sku":"BT-PHS00005","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_1c6b8c0a-5e8c-4c8e-8334-3731b4c2ad19.png?v=1705642110","url":"https:\/\/danabiosci.com\/products\/new-product-571630","provider":"Dana Bioscience","version":"1.0","type":"link"}