{"product_id":"new-product-571470","title":"VHL Polyclonal Antibody","description":"\u003cp\u003eVon Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL is the basis of familial inheritance of VHL syndrome. The protein encoded by VHL is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G\/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.\u003c\/p\u003e\n\u003cp\u003eThe VHL Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of Von Hippel-Lindau (VHL) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a specific region of the VHL protein sequence.\u003cbr\u003e\u003cbr\u003eThe VHL Polyclonal Antibody exhibits exceptional affinity and selectivity towards the VHL protein, enabling accurate and reliable detection in Western blotting, immunohistochemistry, and immunofluorescence applications. It has been extensively validated and optimized to ensure consistent and reproducible results.\u003cbr\u003e\u003cbr\u003eWith its superior sensitivity, the VHL Polyclonal Antibody allows for the detection of even low levels of VHL protein, making it an ideal choice for researchers studying VHL-related diseases and disorders. Its broad reactivity across multiple species, including human, mouse, and rat, further enhances its versatility and applicability in various experimental settings.\u003cbr\u003e\u003cbr\u003eThe VHL Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size of 100 µg, ensuring ample supply for multiple experiments. The antibody is stored at -20°C to maintain its stability and activity.\u003cbr\u003e\u003cbr\u003eIn summary, the VHL Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of VHL protein. Its high specificity, sensitivity, and broad reactivity make it an invaluable asset for researchers in the field of VHL-related research.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542907633944,"sku":"BT-AP09520","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_41bab457-3582-495b-8d7f-9b990bf3fe41.png?v=1705641262","url":"https:\/\/danabiosci.com\/products\/new-product-571470","provider":"Dana Bioscience","version":"1.0","type":"link"}