{"product_id":"new-product-571450","title":"VAV1 Polyclonal Antibody","description":"\u003cp\u003eVAV1 is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The proto-oncogene vav is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK\/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.\u003c\/p\u003e\n\u003cp\u003eThe Vav1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Vav1 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards Vav1. \u003cbr\u003e\u003cbr\u003eVav1 is a key signaling molecule involved in the regulation of various cellular processes, including cell proliferation, differentiation, and migration. It plays a crucial role in the activation of Rho GTPases, which are essential for cytoskeletal rearrangement and cell motility. Dysregulation of Vav1 has been implicated in the development and progression of several diseases, including cancer and autoimmune disorders.\u003cbr\u003e\u003cbr\u003eThe Vav1 Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of Vav1 protein expression in both normal and diseased tissues.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, ready to use for immediate application. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The Vav1 Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reproducible results.\u003cbr\u003e\u003cbr\u003eIn summary, the Vav1 Polyclonal Antibody is a valuable tool for researchers studying Vav1 protein expression and its role in various biological processes. Its high specificity, sensitivity, and versatility make it an ideal choice for a wide range of applications, facilitating in-depth investigations and advancing scientific understanding in the field.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542902489368,"sku":"BT-AP09487","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_6ff9dec4-5c10-4e23-ae2a-667ee6b1cc55.png?v=1705641161","url":"https:\/\/danabiosci.com\/products\/new-product-571450","provider":"Dana Bioscience","version":"1.0","type":"link"}