{"product_id":"new-product-571446","title":"V-ATPase D Polyclonal Antibody","description":"\u003cp\u003eATP6V1D (ATPase H+ transporting V1 subunit D) encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c\" and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. ATP6V1D encodes the V1 domain D subunit protein.\u003c\/p\u003e\n\u003cp\u003eThe V-ATPase D Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of V-ATPase D protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human V-ATPase D protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.\u003cbr\u003e\u003cbr\u003eThe V-ATPase D Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize V-ATPase D protein in various species, including human, mouse, and rat. The antibody has also been shown to detect endogenous V-ATPase D protein in various cell lines and tissues.\u003cbr\u003e\u003cbr\u003eThis antibody is an essential tool for researchers studying the function and regulation of V-ATPase D protein in various biological processes, including lysosomal acidification, bone resorption, and tumor metastasis. Its high specificity and sensitivity make it an ideal reagent for detecting V-ATPase D protein in complex biological samples.\u003cbr\u003e\u003cbr\u003eIn summary, the V-ATPase D Polyclonal Antibody is a highly specific and sensitive antibody that is essential for the detection of V-ATPase D protein in various biological samples. Its extensive validation and broad applicability make it an ideal reagent for researchers studying the function and regulation of V-ATPase D protein in various biological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542901375256,"sku":"BT-AP09482","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_d7a27ae2-7077-41f5-84ec-599f37de1833.png?v=1705641134","url":"https:\/\/danabiosci.com\/products\/new-product-571446","provider":"Dana Bioscience","version":"1.0","type":"link"}