{"product_id":"new-product-571279","title":"TRAIL Polyclonal Antibody","description":"\u003cp\u003eTumor necrosis factor ligand superfamily member 10 encoded by TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A\/TRAILR1, TNFRSF10B\/TRAILR2, TNFRSF10C\/TRAILR3, TNFRSF10D\/TRAILR4, and possibly also to TNFRSF11B\/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C\/TRAILR3, TNFRSF10D\/TRAILR4, and TNFRSF11B\/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8\/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe TRAIL Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human TRAIL protein. The TRAIL Polyclonal Antibody is purified using protein A affinity chromatography and is validated for use in Western blotting, immunohistochemistry, and immunofluorescence assays.\u003cbr\u003e\u003cbr\u003eThe TRAIL Polyclonal Antibody is a valuable tool for researchers studying apoptosis and cancer biology. TRAIL, also known as TNF-related apoptosis-inducing ligand, is a cytokine that induces apoptosis in cancer cells while sparing normal cells. The TRAIL Polyclonal Antibody can be used to detect TRAIL protein expression in various cancer cell lines and tissues, as well as to investigate the mechanisms of TRAIL-induced apoptosis.\u003cbr\u003e\u003cbr\u003eThe TRAIL Polyclonal Antibody is provided in a liquid format and is ready to use for research purposes. It is recommended to store the antibody at -20°C for long-term storage and to avoid repeated freeze-thaw cycles. The TRAIL Polyclonal Antibody is a reliable and high-quality reagent that can help advance research in the fields of cancer biology and apoptosis.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542853337368,"sku":"BT-AP09173","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_36c09c26-b93d-4379-a165-0120a1a2a60f.png?v=1705640281","url":"https:\/\/danabiosci.com\/products\/new-product-571279","provider":"Dana Bioscience","version":"1.0","type":"link"}