{"product_id":"new-product-571164","title":"TFIID Polyclonal Antibody","description":"\u003cp\u003eInitiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. TATA-box-binding protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TBP encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe TFIID Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of TFIID protein in various biological samples. This antibody is produced through a rigorous process, ensuring its high affinity and specificity towards TFIID. \u003cbr\u003e\u003cbr\u003eTFIID, also known as Transcription Factor IID, is a crucial component of the RNA polymerase II pre-initiation complex. It plays a pivotal role in the initiation of transcription by binding to the TATA box promoter element and recruiting other transcription factors. The accurate measurement of TFIID levels is essential for understanding gene expression regulation and its dysregulation in various diseases.\u003cbr\u003e\u003cbr\u003eThe TFIID Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its high sensitivity allows for the detection of low levels of TFIID, enabling precise quantification in complex biological samples. Moreover, this antibody demonstrates minimal cross-reactivity with other proteins, ensuring reliable and accurate results.\u003cbr\u003e\u003cbr\u003eThis product is supplied as a liquid formulation, ready for immediate use. It is available in various sizes to accommodate different experimental needs. Each batch of the TFIID Polyclonal Antibody undergoes rigorous quality control tests to ensure consistent performance and reliability.\u003cbr\u003e\u003cbr\u003eIn summary, the TFIID Polyclonal Antibody is a valuable tool for researchers studying gene expression regulation and its implications in various biological processes and diseases. Its high specificity, sensitivity, and reliability make it an indispensable asset in the field of molecular biology and biomedical research.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542828925208,"sku":"BT-AP08952","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_15dc1d4b-b6cb-4908-8f36-da6f0a95de65.png?v=1705639682","url":"https:\/\/danabiosci.com\/products\/new-product-571164","provider":"Dana Bioscience","version":"1.0","type":"link"}