{"product_id":"new-product-570996","title":"Stat5a Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by STAT5A (signal transducer and activator of transcription 5A) is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL\/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of STAT5A is found to induce the expression of BCL2L1\/BCL-X (L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for STAT5A.\u003c\/p\u003e\n\u003cp\u003eThe STAT5a Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of STAT5a protein in various biological samples. This antibody has been extensively validated for its exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.\u003cbr\u003e\u003cbr\u003eSTAT5a, a member of the signal transducer and activator of transcription (STAT) family, plays a crucial role in mediating cellular responses to cytokines and growth factors. It is involved in the regulation of diverse biological processes, including cell proliferation, differentiation, and survival. The STAT5a Polyclonal Antibody recognizes the phosphorylated and non-phosphorylated forms of STAT5a, enabling comprehensive analysis of its activation status.\u003cbr\u003e\u003cbr\u003eThis antibody exhibits outstanding specificity, exhibiting minimal cross-reactivity with other STAT family members or unrelated proteins. It demonstrates high sensitivity, allowing for the detection of low-abundance STAT5a protein levels. The STAT5a Polyclonal Antibody also exhibits excellent reproducibility, ensuring consistent and reliable results across multiple experiments.\u003cbr\u003e\u003cbr\u003eThe STAT5a Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for easy handling and storage. This antibody has been rigorously tested to ensure optimal performance, providing researchers with a valuable tool for their studies on STAT5a signaling pathways.\u003cbr\u003e\u003cbr\u003eIn summary, the STAT5a Polyclonal Antibody is a superior reagent that offers exceptional specificity, sensitivity, and reproducibility for the detection and quantification of STAT5a protein. Its versatility in various applications makes it an indispensable tool for researchers investigating the role of STAT5a in cellular processes and disease mechanisms.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542792814872,"sku":"BT-AP08640","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_bcc28bf7-ef66-4b5f-96c0-5e89b57a73a6.png?v=1705638750","url":"https:\/\/danabiosci.com\/products\/new-product-570996","provider":"Dana Bioscience","version":"1.0","type":"link"}