{"product_id":"new-product-570871","title":"Smad6 Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by SMAD6 belongs to the SMAD family of proteins, which are related to Drosophila ‘mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta\/activin-signalling. Multiple transcript variants have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe Smad6 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Smad6 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eSmad6 is a crucial member of the Smad family, which plays a pivotal role in the transforming growth factor-beta (TGF-β) signaling pathway. It acts as a negative regulator, inhibiting the activation of downstream signaling molecules and thus modulating TGF-β signaling. Dysregulation of Smad6 has been implicated in various diseases, including cancer, cardiovascular disorders, and skeletal abnormalities.\u003cbr\u003e\u003cbr\u003eThe Smad6 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes endogenous levels of Smad6 protein in both human and animal samples, making it a versatile tool for researchers in diverse fields.\u003cbr\u003e\u003cbr\u003eWith its high sensitivity and specificity, this antibody enables accurate and reliable detection of Smad6 protein expression, facilitating in-depth investigations into the role of Smad6 in various biological processes and disease pathogenesis. Its superior performance ensures reproducible and robust results, making it an indispensable tool for researchers aiming to unravel the complexities of TGF-β signaling and its associated disorders.\u003cbr\u003e\u003cbr\u003eThe Smad6 Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. It has been extensively validated for its performance and quality, guaranteeing consistent and reliable results.\u003cbr\u003e\u003cbr\u003eIn summary, the Smad6 Polyclonal Antibody is a highly specific and sensitive tool that enables accurate detection and analysis of Smad6 protein expression. Its exceptional performance and versatility make it an invaluable asset for researchers investigating the intricate mechanisms of TGF-β signaling and its implications in various diseases.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542765519128,"sku":"BT-AP08395","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_12689c5d-8839-4b27-8ac7-e66a221a0139.png?v=1705638033","url":"https:\/\/danabiosci.com\/products\/new-product-570871","provider":"Dana Bioscience","version":"1.0","type":"link"}