{"product_id":"new-product-570861","title":"Smad2 Polyclonal Antibody","description":"\u003cp\u003eMothers against decapentaplegic homolog 2 encoded by SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.\u003c\/p\u003e\n\u003cp\u003eThe Smad2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Smad2 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein. \u003cbr\u003e\u003cbr\u003eThe Smad2 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated and proven to provide reliable and reproducible results in these assays. \u003cbr\u003e\u003cbr\u003eWith its superior sensitivity, this antibody allows for the detection of even low levels of Smad2 protein, enabling accurate quantification and analysis. Its high specificity ensures minimal cross-reactivity with other proteins, enhancing the accuracy and reliability of experimental data. \u003cbr\u003e\u003cbr\u003eThe Smad2 Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reliable performance from batch to batch. It is supplied in a convenient and ready-to-use format, allowing for easy integration into laboratory workflows. \u003cbr\u003e\u003cbr\u003eIn summary, the Smad2 Polyclonal Antibody is a valuable tool for researchers studying Smad2 protein expression and function. Its high specificity, sensitivity, and reliability make it an essential component in various research applications, contributing to the advancement of scientific knowledge in the field.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542764339480,"sku":"BT-AP08381","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_14b8bbb8-3d1b-4128-8763-ff5fac1bb03a.png?v=1705637991","url":"https:\/\/danabiosci.com\/products\/new-product-570861","provider":"Dana Bioscience","version":"1.0","type":"link"}