{"product_id":"new-product-570854","title":"SLP-76 Polyclonal Antibody","description":"\u003cp\u003eSLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.\u003c\/p\u003e\n\u003cp\u003eThe SLP-76 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of SLP-76 protein expression in various biological samples. This antibody is produced through a rigorous process, ensuring its high affinity and sensitivity towards SLP-76. \u003cbr\u003e\u003cbr\u003eWith its exceptional specificity, this polyclonal antibody enables accurate identification and quantification of SLP-76 protein in Western blotting, immunoprecipitation, and immunofluorescence assays. Its superior performance guarantees reliable and reproducible results, making it an indispensable tool for researchers and scientists in the field of immunology and cell biology.\u003cbr\u003e\u003cbr\u003eThe SLP-76 Polyclonal Antibody exhibits excellent versatility, allowing for its application in a wide range of species, including human, mouse, and rat. Its broad reactivity ensures its suitability for various experimental settings, facilitating comprehensive investigations into the role and function of SLP-76 in different biological systems.\u003cbr\u003e\u003cbr\u003eFurthermore, this antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure batch-to-batch consistency and reliability. Its long shelf life and stability make it a cost-effective choice for long-term experiments and studies.\u003cbr\u003e\u003cbr\u003eIn summary, the SLP-76 Polyclonal Antibody is a highly specific, versatile, and reliable tool that provides accurate detection and analysis of SLP-76 protein expression. Its exceptional performance and quality make it an essential component for researchers aiming to unravel the intricate mechanisms underlying immunological and cellular processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542763421976,"sku":"BT-AP08367","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_e0d2f991-7109-4bf3-b817-994321e00188.png?v=1705637954","url":"https:\/\/danabiosci.com\/products\/new-product-570854","provider":"Dana Bioscience","version":"1.0","type":"link"}