{"product_id":"new-product-570764","title":"SENP3 Polyclonal Antibody","description":"\u003cp\u003eThe reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al. 2006 [PubMed 16738315]).\u003c\/p\u003e\n\u003cp\u003eThe SENP3 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of SENP3 protein expression in various biological samples. This antibody has been extensively validated for its superior performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.\u003cbr\u003e\u003cbr\u003eSENP3, also known as Sentrin-specific protease 3, is a member of the SUMO-specific protease (SENP) family. It plays a crucial role in the regulation of SUMOylation, a post-translational modification process that modulates protein function and cellular processes. SENP3 is involved in the deconjugation of SUMO proteins from their target proteins, thereby regulating their activity and localization.\u003cbr\u003e\u003cbr\u003eThe SENP3 Polyclonal Antibody has been meticulously developed using high-quality materials and advanced techniques to ensure exceptional specificity and sensitivity. It exhibits minimal cross-reactivity with other SENP family members, ensuring accurate and reliable results. This antibody has been extensively tested on a wide range of cell lines and tissues, demonstrating its robust performance and consistent staining patterns.\u003cbr\u003e\u003cbr\u003eIn IHC applications, the SENP3 Polyclonal Antibody shows strong and specific staining of SENP3 protein in formalin-fixed, paraffin-embedded tissues. It provides clear and distinct localization of SENP3 within the cellular compartments, enabling precise analysis of its expression and distribution. The antibody also exhibits excellent performance in IF, allowing for the visualization of SENP3 in live or fixed cells with high resolution and minimal background noise.\u003cbr\u003e\u003cbr\u003eFurthermore, the SENP3 Polyclonal Antibody is highly suitable for WB analysis, enabling the detection of SENP3 protein in whole cell lysates or tissue extracts. It exhibits a strong and specific band at the expected molecular weight, facilitating accurate quantification and comparison of SENP3 expression levels across different samples.\u003cbr\u003e\u003cbr\u003eIn summary, the SENP3 Polyclonal Antibody is a reliable and versatile tool for the detection and analysis of SENP3 protein expression. Its exceptional specificity, sensitivity, and robust performance make it an ideal choice for researchers studying the role of SENP3 in various biological processes and diseases.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542708371736,"sku":"BT-AP08206","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_5f61ff27-50c6-4187-ba11-86396d0cb7df.png?v=1705637478","url":"https:\/\/danabiosci.com\/products\/new-product-570764","provider":"Dana Bioscience","version":"1.0","type":"link"}