{"product_id":"new-product-570710","title":"RUNX2 Polyclonal Antibody","description":"\u003cp\u003eRUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Runt-related transcription factor 2 is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.\u003c\/p\u003e\n\u003cp\u003eThe RUNX2 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of RUNX2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human RUNX2 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.\u003cbr\u003e\u003cbr\u003eThe RUNX2 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes a single band of approximately 57 kDa in Western blot analysis of human, mouse, and rat cell lysates. In addition, the antibody has been shown to detect endogenous RUNX2 protein in various tissues, including bone, cartilage, and teeth.\u003cbr\u003e\u003cbr\u003eThis antibody is an essential tool for researchers studying the role of RUNX2 in bone development, osteoblast differentiation, and bone-related diseases such as osteoporosis and osteosarcoma. It can also be used to investigate the involvement of RUNX2 in other biological processes, including cell proliferation, apoptosis, and angiogenesis.\u003cbr\u003e\u003cbr\u003eIn summary, the RUNX2 Polyclonal Antibody is a reliable and high-quality reagent that provides accurate and reproducible results in various applications. Its specificity and sensitivity make it an ideal tool for researchers studying the function and regulation of RUNX2 protein in various biological systems.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542693560600,"sku":"BT-AP08061","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_6c4b0b76-9a4b-4501-8d01-ffc370432f32.png?v=1705637197","url":"https:\/\/danabiosci.com\/products\/new-product-570710","provider":"Dana Bioscience","version":"1.0","type":"link"}