{"product_id":"new-product-570546","title":"Ref-1 (Acetyl Lys7) Polyclonal Antibody","description":"\u003cp\u003eApurinic\/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. APEX1 encodes the major AP endonuclease in human cells. Splice variants have been found for APEX1; all encode the same protein.\u003c\/p\u003e\n\u003cp\u003eThe Ref-1 (Acetyl Lys7) Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of Ref-1 protein in various biological samples. This antibody has been developed using advanced techniques and is produced in a state-of-the-art facility to ensure consistent and high-quality results.\u003cbr\u003e\u003cbr\u003eThe Ref-1 protein, also known as APE1 (Apurinic\/apyrimidinic endonuclease 1), plays a crucial role in DNA repair and redox regulation. It is involved in the base excision repair pathway, which is responsible for repairing damaged DNA. Additionally, Ref-1 is known to regulate the activity of several transcription factors, making it an important player in gene expression regulation.\u003cbr\u003e\u003cbr\u003eThe Acetyl Lys7 modification of Ref-1 has been shown to have functional significance in various cellular processes. This polyclonal antibody specifically recognizes and binds to the acetylated form of Lysine 7 on the Ref-1 protein, allowing for precise detection and quantification of this modified protein.\u003cbr\u003e\u003cbr\u003eThe Ref-1 (Acetyl Lys7) Polyclonal Antibody has been extensively validated for its specificity and sensitivity. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results. This antibody is suitable for various applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eWith its high affinity and specificity, the Ref-1 (Acetyl Lys7) Polyclonal Antibody is an indispensable tool for researchers studying DNA repair, redox regulation, and gene expression. Its reliable performance and consistent results make it an excellent choice for both basic research and clinical applications.\u003cbr\u003e\u003cbr\u003eOrder your Ref-1 (Acetyl Lys7) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of DNA repair and gene regulation.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542647718168,"sku":"BT-AP07733","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_125cc430-4790-461d-9961-c7ee0f112835.png?v=1705636295","url":"https:\/\/danabiosci.com\/products\/new-product-570546","provider":"Dana Bioscience","version":"1.0","type":"link"}