{"product_id":"new-product-570397","title":"PTEN (Acetyl Lys402) Polyclonal Antibody","description":"\u003cp\u003ePTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases,phosphatase and tensin homolog preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of PTEN is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.\u003c\/p\u003e\n\u003cp\u003eThe PTEN (Acetyl Lys402) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of PTEN protein in various biological samples. This antibody is produced using advanced techniques and is rigorously validated to ensure optimal performance and reliability.\u003cbr\u003e\u003cbr\u003eThe PTEN protein, also known as phosphatase and tensin homolog, plays a crucial role in regulating cell growth, proliferation, and survival. It acts as a tumor suppressor by negatively regulating the PI3K\/AKT signaling pathway, which is frequently dysregulated in various cancers. Therefore, the accurate measurement of PTEN protein levels is of great importance in cancer research and diagnosis.\u003cbr\u003e\u003cbr\u003eThe PTEN (Acetyl Lys402) Polyclonal Antibody is specifically designed to target the acetylated form of PTEN at Lys402, a critical residue involved in the regulation of PTEN activity. This antibody exhibits high affinity and specificity towards the acetylated PTEN protein, enabling precise detection and quantification.\u003cbr\u003e\u003cbr\u003eThis antibody is suitable for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively tested and validated in multiple cell lines and tissue samples, ensuring reliable and reproducible results. Additionally, it demonstrates minimal cross-reactivity with other proteins, further enhancing its specificity.\u003cbr\u003e\u003cbr\u003eThe PTEN (Acetyl Lys402) Polyclonal Antibody is supplied as a liquid formulation, making it convenient and easy to use. It is provided in a vial with an optimized concentration, allowing for efficient and cost-effective experiments. The antibody is also available in different sizes to accommodate various experimental needs.\u003cbr\u003e\u003cbr\u003eIn summary, the PTEN (Acetyl Lys402) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of PTEN protein. Its advanced design, rigorous validation, and broad applicability make it an essential component in cancer research and diagnosis.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542617440536,"sku":"BT-AP07468","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_ca04e824-7b26-404a-954d-a14601bd6ae0.png?v=1705635411","url":"https:\/\/danabiosci.com\/products\/new-product-570397","provider":"Dana Bioscience","version":"1.0","type":"link"}