{"product_id":"new-product-570293","title":"PML Polyclonal Antibody","description":"\u003cp\u003ePromyelocytic leukemia encoded by PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. PML is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.\u003c\/p\u003e\n\u003cp\u003eThe PML Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and analysis of the Promyelocytic Leukemia (PML) protein. This antibody is produced through a rigorous process of immunization using a purified recombinant PML protein, ensuring its high affinity and specificity towards the target antigen.\u003cbr\u003e\u003cbr\u003eThe PML Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its superior sensitivity allows for the detection of even low levels of PML protein expression, enabling accurate and reliable results in research and diagnostic settings.\u003cbr\u003e\u003cbr\u003eThis antibody is manufactured under strict quality control measures, ensuring batch-to-batch consistency and reproducibility. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation steps.\u003cbr\u003e\u003cbr\u003eThe PML Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue sections, and whole-cell extracts. Its versatility and robustness make it an ideal choice for researchers and clinicians studying PML protein expression and its implications in various diseases, including cancer and viral infections.\u003cbr\u003e\u003cbr\u003eWith its exceptional performance, high specificity, and ease of use, the PML Polyclonal Antibody is an indispensable tool for any laboratory or research facility aiming to unravel the intricate mechanisms underlying PML protein function and its role in disease pathogenesis.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542601253144,"sku":"BT-AP07298","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_47a651ae-26c8-4b7e-bf98-492364c01429.png?v=1705634802","url":"https:\/\/danabiosci.com\/products\/new-product-570293","provider":"Dana Bioscience","version":"1.0","type":"link"}