{"product_id":"new-product-570278","title":"PLB Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by PLN (phospholamban)is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in PLN are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.\u003c\/p\u003e\n\u003cp\u003eThe PLB Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of phospholamban (PLB) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human PLB protein. The resulting polyclonal antibody exhibits high affinity and specificity towards PLB protein, making it an ideal tool for research applications in the fields of cardiology, physiology, and biochemistry.\u003cbr\u003e\u003cbr\u003eThe PLB Polyclonal Antibody is purified using a combination of protein A and peptide affinity chromatography, ensuring high purity and minimal cross-reactivity with other proteins. This antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to detect both phosphorylated and non-phosphorylated forms of PLB protein.\u003cbr\u003e\u003cbr\u003eThe PLB Polyclonal Antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is available in various sizes to meet the needs of different research applications. This antibody is manufactured in compliance with strict quality control standards to ensure consistent performance and reproducibility.\u003cbr\u003e\u003cbr\u003eIn summary, the PLB Polyclonal Antibody is a reliable and high-quality immunological reagent that offers exceptional sensitivity and specificity for the detection and quantification of PLB protein in various biological samples. Its versatility and ease of use make it an essential tool for researchers in the fields of cardiology, physiology, and biochemistry.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47542600499480,"sku":"BT-AP07256","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_bfff666d-0a6d-40e8-ac76-26bbc37dafe1.png?v=1705634742","url":"https:\/\/danabiosci.com\/products\/new-product-570278","provider":"Dana Bioscience","version":"1.0","type":"link"}